E-ISSN 2277-338X | ISSN 2320-4664
 

Review Article 


Mutations in genes onset the disease of cancer

Lipda Chantayasakorn.

Abstract
Cancer is a genetic disease, meaning it is caused by alterations in genes that control how our cells behave, mainly how they divide and grow. Proteins do a lot of the work in our cells, and genes provide the instructions for making them. Specific gene mutations can cause cells to escape standard growth regulators and turn cancerous. Some cancer-causing gene alterations, for example, enhance the synthesis of a protein that causes cells to proliferate. Others cause a malformed and hence non-functional form of a protein that typically repairs cellular damage to be produced. If the mutations are present in germ cells, the body’s reproductive cells, we can inherit cancer-causing genetic abnormalities from our parents. Such mutations, known as germline mutations, can be identified in every cell of the offspring. Cancer-causing genetic mutations can also be acquired over ones lifespan due to cell division errors or exposure to carcinogenic compounds that damage DNA, such as some chemicals in tobacco smoke, and radiation, such as UV rays from the sun. Somatic (or acquired) alterations are genetic changes that occur after conception. Cancer cells, on average, exhibit more genetic alterations than healthy cells. However, each person cancer has a unique set of genetic mutations. Some of these alterations could be the effect rather than the cause of cancer. Additional alterations will occur as the malignancy progresses. Cancer cells may have diverse genetic alterations even within the same tumor.

Key words: Cancers; Cancer Genetics; Genetic Abnormalities


 
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Pubmed Style

Lipda Chantayasakorn. Mutations in genes onset the disease of cancer. doi:10.5455/ijmsph.2021.07071202111082021


Web Style

Lipda Chantayasakorn. Mutations in genes onset the disease of cancer. http://www.ijmsph.com/?mno=94860 [Access: October 03, 2021]. doi:10.5455/ijmsph.2021.07071202111082021


AMA (American Medical Association) Style

Lipda Chantayasakorn. Mutations in genes onset the disease of cancer. doi:10.5455/ijmsph.2021.07071202111082021



Vancouver/ICMJE Style

Lipda Chantayasakorn. Mutations in genes onset the disease of cancer. doi:10.5455/ijmsph.2021.07071202111082021



Harvard Style

Lipda Chantayasakorn (2021) Mutations in genes onset the disease of cancer. doi:10.5455/ijmsph.2021.07071202111082021



Turabian Style

Lipda Chantayasakorn. 2021. Mutations in genes onset the disease of cancer. doi:10.5455/ijmsph.2021.07071202111082021



Chicago Style

Lipda Chantayasakorn. "Mutations in genes onset the disease of cancer." doi:10.5455/ijmsph.2021.07071202111082021



MLA (The Modern Language Association) Style

Lipda Chantayasakorn. "Mutations in genes onset the disease of cancer." doi:10.5455/ijmsph.2021.07071202111082021



APA (American Psychological Association) Style

Lipda Chantayasakorn (2021) Mutations in genes onset the disease of cancer. doi:10.5455/ijmsph.2021.07071202111082021





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