E-ISSN 2277-338X | ISSN 2320-4664
 

Case Report 


Amyotropic lateral sclerosis as a para-neoplastic manifestation of gastric adenocarcinoma - A rare case report

Subrata Chakrabarti, Koushik Pan.

Abstract
Motor neuron diseases(MND) have been reported as a rare paraneoplastic syndrome (PNS) of a systemic neoplasm.Amyotropic Lateral Sclerosis as a paraneoplastic manifestation of gastric carcinoma is even rarer. We present a patient with amyotrophic lateral sclerosis (ALS) in association with adenocarcinoma of stomach. A 48year old man presented with a four months history of progressive dysphagia, spastic dysarthria and marked fasciculation in his atrophic tongue. Gag reflexes were diminished bilaterally. There was significant atrophy in thenar and hypothenar areas of both hands and dorsum of both feet.Electromyography result was compatible with diffuse motor neuronopathy with active denervation.MRI brain showed classical findings of ALS. Upper GI endoscopic study showed ulcerated mucosa in body of stomach. Histological biopsy of stomach confirmed the presence of adenocarcinoma. The importance of considering a paraneoplastic syndrome in a patient with presentation of ALS is that it can lead to searching for underlying neoplasm before its apparent signs and symptoms develop and a scope to initiate treatment for primary carcinoma. Again treating the underlying neoplasm may halt or even resolve the neurologic signs and symptoms.

Key words: Motor Neuron Diseases; Amyotrophic Lateral Sclerosis; Paraneoplastic Syndrome; Gastric Adenocarcinoma


 
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How to Cite this Article
Pubmed Style

Subrata Chakrabarti, Koushik Pan. Amyotropic lateral sclerosis as a para-neoplastic manifestation of gastric adenocarcinoma - A rare case report. Int J Med Sci Public Health. 2014; 3(3): 380-381. doi:10.5455/ijmsph.2014.090120141


Web Style

Subrata Chakrabarti, Koushik Pan. Amyotropic lateral sclerosis as a para-neoplastic manifestation of gastric adenocarcinoma - A rare case report. http://www.ijmsph.com/?mno=49504 [Access: August 24, 2019]. doi:10.5455/ijmsph.2014.090120141


AMA (American Medical Association) Style

Subrata Chakrabarti, Koushik Pan. Amyotropic lateral sclerosis as a para-neoplastic manifestation of gastric adenocarcinoma - A rare case report. Int J Med Sci Public Health. 2014; 3(3): 380-381. doi:10.5455/ijmsph.2014.090120141



Vancouver/ICMJE Style

Subrata Chakrabarti, Koushik Pan. Amyotropic lateral sclerosis as a para-neoplastic manifestation of gastric adenocarcinoma - A rare case report. Int J Med Sci Public Health. (2014), [cited August 24, 2019]; 3(3): 380-381. doi:10.5455/ijmsph.2014.090120141



Harvard Style

Subrata Chakrabarti, Koushik Pan (2014) Amyotropic lateral sclerosis as a para-neoplastic manifestation of gastric adenocarcinoma - A rare case report. Int J Med Sci Public Health, 3 (3), 380-381. doi:10.5455/ijmsph.2014.090120141



Turabian Style

Subrata Chakrabarti, Koushik Pan. 2014. Amyotropic lateral sclerosis as a para-neoplastic manifestation of gastric adenocarcinoma - A rare case report. International Journal of Medical Science and Public Health, 3 (3), 380-381. doi:10.5455/ijmsph.2014.090120141



Chicago Style

Subrata Chakrabarti, Koushik Pan. "Amyotropic lateral sclerosis as a para-neoplastic manifestation of gastric adenocarcinoma - A rare case report." International Journal of Medical Science and Public Health 3 (2014), 380-381. doi:10.5455/ijmsph.2014.090120141



MLA (The Modern Language Association) Style

Subrata Chakrabarti, Koushik Pan. "Amyotropic lateral sclerosis as a para-neoplastic manifestation of gastric adenocarcinoma - A rare case report." International Journal of Medical Science and Public Health 3.3 (2014), 380-381. Print. doi:10.5455/ijmsph.2014.090120141



APA (American Psychological Association) Style

Subrata Chakrabarti, Koushik Pan (2014) Amyotropic lateral sclerosis as a para-neoplastic manifestation of gastric adenocarcinoma - A rare case report. International Journal of Medical Science and Public Health, 3 (3), 380-381. doi:10.5455/ijmsph.2014.090120141





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