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Heat shock and the heat shock proteins: An overview

Sumira Bashir, Humaira Bashir, Syed Shuja Qadri.

Cited by (1)

Abstract
Organisms are exposed to a variety of stressful condition that damage important cellular structures and interfere with essential functions. In response to heat and other insults, cells activate an ancient signalling pathway leading to the transient expression of heat shock or heat stress proteins (HSPs). HSPs exhibit sophisticated protection mechanisms that protect the damaged cells. HSPs assist in protein folding, translocation and assembly of newly synthesized polypeptides. They also stabilize proteins during heat shock and other stresses, thus contributing to cell survival after injury. The elevated expression of stress proteins is considered to be a universal response to adverse conditions. In this Review we summarize the concepts of the HSPs protective mechanism.

Key words: Heat Shock; Polypeptides; Cellular Structures; Heat Stress Proteins


 
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REFERENCES
1. Ritossa F. A new puffing pattern induced by temperature shock and DNP in Drosophila. Experientia.1962; 18:571-573. [DOI via Crossref]   
2. Feder ME, Hofmann GE. Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu Rev Physiol.1999; 61: 243-82. [DOI via Crossref]    [Pubmed]   
3. Kalmar B. Induction of heat shock proteins for protection against oxidative stress Adv Drug Deliv Rev.2009. 61(4):310-318. [DOI via Crossref]    [Pubmed]   
4. Makhatadze GI, Privalov PL. On the entropy of protein folding. Protein Sci. 1996; 5(3):507-510. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
5. Minton AP. Implications of macromolecular crowding for protein assembly. CurrOpinStruct Biol. 2000. 10(1); 34-9. [DOI via Crossref]   
6. Welch WJ, Suhan JP. Morphological study of the mammalian stress response: characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment. J Cell Biol. 1985; 101(4):1198-1211. [DOI via Crossref]   
7. Boulon S, Westman BJ, Hutten S, Boisvert FM, Lamond AI. The nucleolus under stress. Mol Cell. 2010; 40(2):216-227. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
8. Patriarca EJ, Maresca B. Acquired thermotolerance following heat shock protein synthesis prevents impairment of mitochondrial ATPase activity at elevated temperatures in Saccharomyces cerevisiae. Exp Cell Res. 1990; 190(1):57-64. [DOI via Crossref]   
9. Mayer M P, Bukau B. Hsp70 chaperones: Cellular functions and molecular mechanism. Cell Mol Life Sci. 2005; 62(6): 670-684. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
10. Daugaard M, Rohde M, Jaattela M. The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Lett.2007; 581(19):3702-3710. [DOI via Crossref]    [Pubmed]   
11. Willmund F, del Alamo M, Pechmann S, Chen T, Albanèse V, Dammer EB, et al. The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis. Cell. 2013; 152(1-2):196-209. [DOI via Crossref]    [Pubmed]   
12. Zhu X, Zhao X, Burkholder WF, Gragerov A, Ogata CM, Gottesman ME, et al. Structural analysis of substrate binding by the molecular chaperone DnaK. Science. 1996; 272(5268):1606-14. [DOI via Crossref]    [Pubmed]   
13. Flaherty KM, DeLuca-Flaherty C, McKay DB. Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature. 1990; 346(6285):623-628. [DOI via Crossref]    [Pubmed]   
14. Pfanner A. Molecular chaperones: towards a characterization of the heat-shock protein 70 family. Trends in Cell Biology. 1997; 7(3):129-33. [DOI via Crossref]   
15. Rampelt H, Mayer MP, Bukau B. Nucleotide exchange factors for Hsp70 chaperones. Methods Mol Biol. 2011; 787:83-91. [DOI via Crossref]    [Pubmed]   
16. Jiang J, Maes EG, Taylor AB, Wang L, Hinck AP, Lafer EM, Sousa R. Structural Basis of J Co-chaperone Binding and Regulation of Hsp70. Mol Cell. 2007; 28(3):422-433. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
17. Kampinga HH, Craig EA. The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nat Rev Mol Cell Biol. 2010; 11(8): 579-592. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
18. Grimshaw JP, Jelesarov I, Schönfeld HJ, Christen P. Reversible thermal transition in GrpE, the nucleotide exchange factor of the DnaK heat-shock system. J Biol Chem. 2001;276(9): 6098-6104. [DOI via Crossref]    [Pubmed]   
19. Grimshaw JP, Jelesarov I, Siegenthaler RK, Christen P. Thermosensor action of GrpE. The DnaK chaperone system at heat shock temperatures. J Biol Chem. 2003; 278(21):19048-53. [DOI via Crossref]    [Pubmed]   
20. Siegenthaler RK, Grimshaw JPA, Christen P. Immediate response of the DnaK molecular chaperone system to heat shock. FEBS Lett. 2004; 562(1-3):105-110 [DOI via Crossref]   
21. Pratt WB, Toft DO. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. ExpBiol Med (Maywood). 2003; 228(2):111-33.
22. Johnson JL, Brown C. Plasticity of the Hsp90 chaperone machine in divergent eukaryotic organisms. Cell Stress Chaperones. 2009; 14(1): 83-94. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
23. Taipale M, Jarosz DF, Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat RevMol Cell Biol. 2010; 11(7):515-528. [DOI via Crossref]    [Pubmed]   
24. Prodromou C, Pearl LH. Structure and functional relationships of Hsp90. Curr Cancer Drug Targets. 2003; 3(5):301-23. [DOI via Crossref]   
25. Pearl LH, Prodromou C. Structure and mechanism of the Hsp90 molecular chaperone machinery.Annu Rev Biochem. 2006; 75:271- 294. [DOI via Crossref]    [Pubmed]   
26. Brown MA, Zhu L, Schmidt C, Tucker PW. Hsp90—from signal transduction to cell transformation. 2007; 363(2):241-246.
27. Cheng MY, Hartl FU, Martin J, Pollock RA, Kalousek F, Neupert W, et al. Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature.1989; 337(6208):620-625. [DOI via Crossref]    [Pubmed]   
28. Goloubinoff P, Christeller JT, Gatenby AA, Lorimer GH Reconstitution of active dimericribulosebisphosphate carboxylase from an unfoleded state depends on twochaperonin proteins and Mg-ATP. Nature. 1989; 342 (6252):884-9. [DOI via Crossref]    [Pubmed]   
29. Lubben TH, Gatenby AA, Donaldson GK, Lorimer GH, Viitanen PV. Identification of a groES-like chaperonin in mitochondria that facilitates protein folding. ProcNatlAcadSci USA. 1990; 87(19):7683-7687. [DOI via Crossref]   
30. Haslbeck M, Franzmann T, Weinfurtner D, Buchner J. Some like it hot: the structure and function of small heat-shock proteins. Nat StructMol Biol. 2005; 12(10):842-846. [DOI via Crossref]    [Pubmed]   
31. Sun Y, MacRae TH. Small heat shock proteins: molecular structure and chaperone function. Cell Mol Life Sci. 2005; 62(21):2460-2476. [DOI via Crossref]    [Pubmed]   
32. Narberhaus F. α-Crystallin-type heat shock proteins: socializing minichaperones in the context of a multichaperone network. MicrobiolMol Bio Rev. 2002; 66(1):64-93. [DOI via Crossref]    [PMC Free Fulltext]   
33. Bova MP, Huang Q, Ding L. Horwitz J. Subunit exchange,conformational stability, and chaperone-like function of the small heat shock protein 16.5 from Methanococcusjannaschii. J Biol Chem. 2002; 277(41):38468-75. [DOI via Crossref]    [Pubmed]   
34. Fan GC, Chu G, Kranias E.G. Hsp20 and its cardioprotection, Trends Cardiovasc Med. 2005; 15(4):138-141. [DOI via Crossref]    [Pubmed]   
35. Fuchs LC, Giulumian AD, Knoepp L, Pipkin W, Dickinson M, Hayles C, et al. Stress causes decrease in vascular relaxation linked with altered phosphorylation of heat shock proteins, Am J PhysiolRegulIntegr Comp Physiol. 2000; 279(2): R492-R498 [Pubmed]   
36. Arrigo AP. In search of the molecular mechanism by which small stress proteins counteract apoptosis during cellular differentiation. J Cell Biochem. 2005; 94(2):241-246. [DOI via Crossref]    [Pubmed]   
37. Mounnier N, Arrigo AP. Actin cytoskeleton and small heat shock proteins: how do they interact? Cell Stress Chaperones. 2002; 7(2):167-176 [DOI via Crossref]   
38. Voellmy R, Boellmann F. Chaperone regulation of the heat shock protein response. AdvExp Med Biol. 2007; 594: 89-99. [DOI via Crossref]    [Pubmed]   
39. Rodriguez F, Arsene P, Rist W, Rudiger S, Mergener J, Mayer MP, et al. Molecular basis for regulation of the heat shock transcription factor sigma32 by the DnaK and DnaJ chaperones. Mol Cell. 2008; 32(3): 347-358. [DOI via Crossref]    [Pubmed]   
40. Akerfelt M, Morimoto RI, Sistonen L. Heat shock factors:integrators of cell stress, development and lifespan. Nat Rev Mol Cell Biol. 2010;11(8): 545-555. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

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How to Cite this Article
Pubmed Style

Sumira Bashir, Humaira Bashir, Syed Shuja Qadri. Heat shock and the heat shock proteins: An overview. Int J Med Sci Public Health. 2013; 2(3): 489-494. doi:10.5455/ijmsph.2013.100620131


Web Style

Sumira Bashir, Humaira Bashir, Syed Shuja Qadri. Heat shock and the heat shock proteins: An overview. http://www.ijmsph.com/?mno=38858 [Access: August 24, 2019]. doi:10.5455/ijmsph.2013.100620131


AMA (American Medical Association) Style

Sumira Bashir, Humaira Bashir, Syed Shuja Qadri. Heat shock and the heat shock proteins: An overview. Int J Med Sci Public Health. 2013; 2(3): 489-494. doi:10.5455/ijmsph.2013.100620131



Vancouver/ICMJE Style

Sumira Bashir, Humaira Bashir, Syed Shuja Qadri. Heat shock and the heat shock proteins: An overview. Int J Med Sci Public Health. (2013), [cited August 24, 2019]; 2(3): 489-494. doi:10.5455/ijmsph.2013.100620131



Harvard Style

Sumira Bashir, Humaira Bashir, Syed Shuja Qadri (2013) Heat shock and the heat shock proteins: An overview. Int J Med Sci Public Health, 2 (3), 489-494. doi:10.5455/ijmsph.2013.100620131



Turabian Style

Sumira Bashir, Humaira Bashir, Syed Shuja Qadri. 2013. Heat shock and the heat shock proteins: An overview. International Journal of Medical Science and Public Health, 2 (3), 489-494. doi:10.5455/ijmsph.2013.100620131



Chicago Style

Sumira Bashir, Humaira Bashir, Syed Shuja Qadri. "Heat shock and the heat shock proteins: An overview." International Journal of Medical Science and Public Health 2 (2013), 489-494. doi:10.5455/ijmsph.2013.100620131



MLA (The Modern Language Association) Style

Sumira Bashir, Humaira Bashir, Syed Shuja Qadri. "Heat shock and the heat shock proteins: An overview." International Journal of Medical Science and Public Health 2.3 (2013), 489-494. Print. doi:10.5455/ijmsph.2013.100620131



APA (American Psychological Association) Style

Sumira Bashir, Humaira Bashir, Syed Shuja Qadri (2013) Heat shock and the heat shock proteins: An overview. International Journal of Medical Science and Public Health, 2 (3), 489-494. doi:10.5455/ijmsph.2013.100620131





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