E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation

Shaista Yaqoob, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, Shahnawaz Khaliq.

Abstract
Background: Direct laryngoscopy and intubation are associated with the pressor response which leads to increase in blood pressure (BP) and heart rate (HR) which may be tolerated by young healthy individuals but can prove detrimental in elderly and comorbid patients. Hence, some premedication agents are administered to suppress these responses.

Objectives: In this study, we compared gabapentin and combination of gabapentin and labetalol with a placebo group to study their effect on attenuation of these pressor responses.

Materials and Methods: A total of 90 patients belonging to American Society of Anesthesiologists Class I and II were divided into three Groups A, B, and C of 30 patients each. 1 h before induction of anesthesia patients in Group A received gabapentin 800 mg and in Group B received 400 mg of gabapentin plus 50 mg of labetalol orally, while patients in Group C did not receive any drug and acted as control. Mean arterial pressure (MAP) and HR were recorded in all the three groups at baseline and at 0, 1, 3, 5, and 10 min after tracheal intubation.

Results: Demographic characteristics were comparable in all the three groups. The baseline HR and MAP were also comparable in all the three groups and were statistically insignificant (P > 0.05). However, after tracheal intubation, there was significant increase in HR and MAP in the control Group (C), whereas in Group A and B the response was attenuated and was statistically significant (P = 0.05). Among the two study groups, BP was better attenuated by gabapentin, whereas the combination of gabapentin and labetalol abolishes HR response better.

Conclusion: We conclude gabapentin alone and in combination with labetalol attenuates the hemodynamic response to laryngoscopy and intubation.

Key words: Laryngoscopy; Intubation; Gabapentin; Labetalol; Pressor Response


 
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Pubmed Style

Yaqoob S, Gani TT, Mir AH, Yousuf A, Mir AW, Khaliq S. A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. Int J Med Sci Public Health. 2018; 7(1): 58-62. doi:10.5455/ijmsph.2018.0926825112017


Web Style

Yaqoob S, Gani TT, Mir AH, Yousuf A, Mir AW, Khaliq S. A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. http://www.ijmsph.com/?mno=278282 [Access: July 18, 2018]. doi:10.5455/ijmsph.2018.0926825112017


AMA (American Medical Association) Style

Yaqoob S, Gani TT, Mir AH, Yousuf A, Mir AW, Khaliq S. A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. Int J Med Sci Public Health. 2018; 7(1): 58-62. doi:10.5455/ijmsph.2018.0926825112017



Vancouver/ICMJE Style

Yaqoob S, Gani TT, Mir AH, Yousuf A, Mir AW, Khaliq S. A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. Int J Med Sci Public Health. (2018), [cited July 18, 2018]; 7(1): 58-62. doi:10.5455/ijmsph.2018.0926825112017



Harvard Style

Yaqoob, S., Gani, T. T., Mir, A. H., Yousuf, A., Mir, A. W. & Khaliq, S. (2018) A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. Int J Med Sci Public Health, 7 (1), 58-62. doi:10.5455/ijmsph.2018.0926825112017



Turabian Style

Yaqoob, Shaista, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, and Shahnawaz Khaliq. 2018. A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. International Journal of Medical Science and Public Health, 7 (1), 58-62. doi:10.5455/ijmsph.2018.0926825112017



Chicago Style

Yaqoob, Shaista, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, and Shahnawaz Khaliq. "A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation." International Journal of Medical Science and Public Health 7 (2018), 58-62. doi:10.5455/ijmsph.2018.0926825112017



MLA (The Modern Language Association) Style

Yaqoob, Shaista, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, and Shahnawaz Khaliq. "A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation." International Journal of Medical Science and Public Health 7.1 (2018), 58-62. Print. doi:10.5455/ijmsph.2018.0926825112017



APA (American Psychological Association) Style

Yaqoob, S., Gani, T. T., Mir, A. H., Yousuf, A., Mir, A. W. & Khaliq, S. (2018) A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. International Journal of Medical Science and Public Health, 7 (1), 58-62. doi:10.5455/ijmsph.2018.0926825112017





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