E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Genetic polymorphisms in DNA repair genes (hOGG1 & APE1) and their association with oral cancer susceptibility in rural Indian population: a hospital based case-control study

Kailas D Datkhile, Madhavi N Patil, Tejasvi S Khamkar, Rohit D Vhaval, Pratik P Durgawale, Pandurang G Chougule, Anand Gudur, Satish V Kakade.

Abstract
Background: Smoking and alcohol related head and neck cancer is a major concern of health risk in urban and rural areas of India.

Objective: This study was aimed to determine the frequency of polymorphisms in DNA repair genes, hOGG1 at codon (cd) 326 and APE1 at cd 148 in patients of oral cancer from Maharashtra and to evaluate their association with oral cancer development.

Materials and Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze gene polymorphisms in 200 patients with oral cancer and 200 age and sex matched disease-free controls were used.

Result: The results obtained from the present study indicated that there was no significant difference in the genotype distribution between oral cancer patients and controls for APE1 (p>0.05). The result showed that allele frequencies of hOGG1Cys326 (OR= 8.73; 95% CI= (2.51-30.39); p= <0.0001) genotype significantly increased the risk of head and neck cancer.

Conclusion: This study indicates that polymorphisms in cd326 of hOGG1 gene could play a role in modifying genetic susceptibility of individual to head and neck cancer in Maharashtrian patients.

Key words: hOGG1, APE1, PCR-RFLP, genetic polymorphism


 
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Pubmed Style

Kailas D Datkhile, Madhavi N Patil, Tejasvi S Khamkar, Rohit D Vhaval, Pratik P Durgawale, Pandurang G Chougule, Anand Gudur, Satish V Kakade. Genetic polymorphisms in DNA repair genes (hOGG1 & APE1) and their association with oral cancer susceptibility in rural Indian population: a hospital based case-control study. Int J Med Sci Public Health. 2017; 6(1): 23-28. doi:10.5455/ijmsph.2016.07062016541


Web Style

Kailas D Datkhile, Madhavi N Patil, Tejasvi S Khamkar, Rohit D Vhaval, Pratik P Durgawale, Pandurang G Chougule, Anand Gudur, Satish V Kakade. Genetic polymorphisms in DNA repair genes (hOGG1 & APE1) and their association with oral cancer susceptibility in rural Indian population: a hospital based case-control study. http://www.ijmsph.com/?mno=231198 [Access: April 23, 2019]. doi:10.5455/ijmsph.2016.07062016541


AMA (American Medical Association) Style

Kailas D Datkhile, Madhavi N Patil, Tejasvi S Khamkar, Rohit D Vhaval, Pratik P Durgawale, Pandurang G Chougule, Anand Gudur, Satish V Kakade. Genetic polymorphisms in DNA repair genes (hOGG1 & APE1) and their association with oral cancer susceptibility in rural Indian population: a hospital based case-control study. Int J Med Sci Public Health. 2017; 6(1): 23-28. doi:10.5455/ijmsph.2016.07062016541



Vancouver/ICMJE Style

Kailas D Datkhile, Madhavi N Patil, Tejasvi S Khamkar, Rohit D Vhaval, Pratik P Durgawale, Pandurang G Chougule, Anand Gudur, Satish V Kakade. Genetic polymorphisms in DNA repair genes (hOGG1 & APE1) and their association with oral cancer susceptibility in rural Indian population: a hospital based case-control study. Int J Med Sci Public Health. (2017), [cited April 23, 2019]; 6(1): 23-28. doi:10.5455/ijmsph.2016.07062016541



Harvard Style

Kailas D Datkhile, Madhavi N Patil, Tejasvi S Khamkar, Rohit D Vhaval, Pratik P Durgawale, Pandurang G Chougule, Anand Gudur, Satish V Kakade (2017) Genetic polymorphisms in DNA repair genes (hOGG1 & APE1) and their association with oral cancer susceptibility in rural Indian population: a hospital based case-control study. Int J Med Sci Public Health, 6 (1), 23-28. doi:10.5455/ijmsph.2016.07062016541



Turabian Style

Kailas D Datkhile, Madhavi N Patil, Tejasvi S Khamkar, Rohit D Vhaval, Pratik P Durgawale, Pandurang G Chougule, Anand Gudur, Satish V Kakade. 2017. Genetic polymorphisms in DNA repair genes (hOGG1 & APE1) and their association with oral cancer susceptibility in rural Indian population: a hospital based case-control study. International Journal of Medical Science and Public Health, 6 (1), 23-28. doi:10.5455/ijmsph.2016.07062016541



Chicago Style

Kailas D Datkhile, Madhavi N Patil, Tejasvi S Khamkar, Rohit D Vhaval, Pratik P Durgawale, Pandurang G Chougule, Anand Gudur, Satish V Kakade. "Genetic polymorphisms in DNA repair genes (hOGG1 & APE1) and their association with oral cancer susceptibility in rural Indian population: a hospital based case-control study." International Journal of Medical Science and Public Health 6 (2017), 23-28. doi:10.5455/ijmsph.2016.07062016541



MLA (The Modern Language Association) Style

Kailas D Datkhile, Madhavi N Patil, Tejasvi S Khamkar, Rohit D Vhaval, Pratik P Durgawale, Pandurang G Chougule, Anand Gudur, Satish V Kakade. "Genetic polymorphisms in DNA repair genes (hOGG1 & APE1) and their association with oral cancer susceptibility in rural Indian population: a hospital based case-control study." International Journal of Medical Science and Public Health 6.1 (2017), 23-28. Print. doi:10.5455/ijmsph.2016.07062016541



APA (American Psychological Association) Style

Kailas D Datkhile, Madhavi N Patil, Tejasvi S Khamkar, Rohit D Vhaval, Pratik P Durgawale, Pandurang G Chougule, Anand Gudur, Satish V Kakade (2017) Genetic polymorphisms in DNA repair genes (hOGG1 & APE1) and their association with oral cancer susceptibility in rural Indian population: a hospital based case-control study. International Journal of Medical Science and Public Health, 6 (1), 23-28. doi:10.5455/ijmsph.2016.07062016541





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