E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Association of insulin resistance and adiponectin in metabolic syndrome

Rajkumari Rathore, Neha Sharma, Poornima Dey Sarkar, Anil Bidwai.

Abstract
ABSTRACT
Introduction: Metabolic syndrome (MetS) and decreased adiponectin level have been reported to be clinically associated with type 2 diabetes mellitus and coronary artery disease (CAD). Serum level of adiponectin has been shown to be reduced in several disease states like obesity and diabetes. We investigated the clinical relationship between serum adiponectin level and MetS, and its association with insulin resistance.

Aim & Objective: The present study was designed to compare the fasting adiponectin level with the insulin and insulin resistance between metabolic syndrome patients and healthy subjects. The present study included 140 metabolic syndrome cases (81 men and 59 women) and 100 healthy controls. Metabolic syndrome cases were diagnosed by (NCEP ATP III) criteria. Serum Adiponectin, leptin , insulin, glucose and lipid profile measured and insulin resistance, leptin and adiponectin ratio and BMI were calculated.

Results: All the parameters were significantly (P<0.0001) high in metabolic cases excepts HDL-C and adiponectin which were significantly (P<0.0001) low. In both men and women, adiponectin levels are negatively correlated with triglycerides, VLDL, Insulin, LAR and leptin while positively with HDL-C. Pearson’s correlation coefficient (r) is also performed between LAR level and metabolic factors, the strong positive relation of LAR is obtained with TG, VLDL, and leptin while strong negative relation with adiponectin (p<0.0001).

Conclusion: The present study concluded that decreased adiponectin level observed in metabolic cases, which was low in men compare to women. The finding indicate that adiponectin may have a wide role in metabolism of lipoprotein. It may act as an anti atherosclerotic factor through improving insulin resistance and lipid profile.

Key words: Key Words Metabolic Syndrome, Insulin resistance, Type 2 diabetes Mellitus, Cardio Vascular Disease, Hypoadiponectinemia


 
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Pubmed Style

Rajkumari Rathore, Neha Sharma, Poornima Dey Sarkar, Anil Bidwai. Association of insulin resistance and adiponectin in metabolic syndrome. Int J Med Sci Public Health. 2017; 6(1): 91-95. doi:10.5455/ijmsph.2017.03032016565


Web Style

Rajkumari Rathore, Neha Sharma, Poornima Dey Sarkar, Anil Bidwai. Association of insulin resistance and adiponectin in metabolic syndrome. http://www.ijmsph.com/?mno=220636 [Access: April 23, 2019]. doi:10.5455/ijmsph.2017.03032016565


AMA (American Medical Association) Style

Rajkumari Rathore, Neha Sharma, Poornima Dey Sarkar, Anil Bidwai. Association of insulin resistance and adiponectin in metabolic syndrome. Int J Med Sci Public Health. 2017; 6(1): 91-95. doi:10.5455/ijmsph.2017.03032016565



Vancouver/ICMJE Style

Rajkumari Rathore, Neha Sharma, Poornima Dey Sarkar, Anil Bidwai. Association of insulin resistance and adiponectin in metabolic syndrome. Int J Med Sci Public Health. (2017), [cited April 23, 2019]; 6(1): 91-95. doi:10.5455/ijmsph.2017.03032016565



Harvard Style

Rajkumari Rathore, Neha Sharma, Poornima Dey Sarkar, Anil Bidwai (2017) Association of insulin resistance and adiponectin in metabolic syndrome. Int J Med Sci Public Health, 6 (1), 91-95. doi:10.5455/ijmsph.2017.03032016565



Turabian Style

Rajkumari Rathore, Neha Sharma, Poornima Dey Sarkar, Anil Bidwai. 2017. Association of insulin resistance and adiponectin in metabolic syndrome. International Journal of Medical Science and Public Health, 6 (1), 91-95. doi:10.5455/ijmsph.2017.03032016565



Chicago Style

Rajkumari Rathore, Neha Sharma, Poornima Dey Sarkar, Anil Bidwai. "Association of insulin resistance and adiponectin in metabolic syndrome." International Journal of Medical Science and Public Health 6 (2017), 91-95. doi:10.5455/ijmsph.2017.03032016565



MLA (The Modern Language Association) Style

Rajkumari Rathore, Neha Sharma, Poornima Dey Sarkar, Anil Bidwai. "Association of insulin resistance and adiponectin in metabolic syndrome." International Journal of Medical Science and Public Health 6.1 (2017), 91-95. Print. doi:10.5455/ijmsph.2017.03032016565



APA (American Psychological Association) Style

Rajkumari Rathore, Neha Sharma, Poornima Dey Sarkar, Anil Bidwai (2017) Association of insulin resistance and adiponectin in metabolic syndrome. International Journal of Medical Science and Public Health, 6 (1), 91-95. doi:10.5455/ijmsph.2017.03032016565





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