E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men

ML Edy Parwanto, Suweino Suweino, David Tjahjadi, Hardy Senjaya, Hosea Jaya Edy, Alfred Pakpahan.

Abstract
Background: Sex hormone-binding globulin (SHBG) is a protein. The synthesis of SHBG protein is encoded by SHBG gene. Protein polymorphism of SHBG can occur because of a mutation of D327N exon 8 in SHBG gene. D327N mutation causes the addition of glycosylation so that molecular weight of SHBG protein increases. Protein polymorphism of SHBG is suspected to affect the levels of SHBG, testosterone, and insulin in the blood circulation.

Objective: To determine the effect of protein polymorphism of SHBG on the levels of SHBG, testosterone, and insulin in healthy adult men.

Materials and Methods: Serum samples were collected from 179 healthy adult men. Electrophoresis and western blotting were performed to determine the phenotype of SHBG. All subjects were divided into two groups based on SHBG phenotype; group I (normal SHBG phenotype) n = 159 subjects and group II (variant SHBG phenotype) n = 38 subjects.

Result: The levels of serum SHBG, testosterone, and insulin were measured using radioimmunoassay method. The levels of SHBG, total testosterone, and free testosterone between normal SHBG phenotype do not differ with variant SHBG phenotype (p > 0.05), but insulin levels between normal SHBG phenotype compared with variant SHBG phenotype was different (p < 0.05).

Conclusion: Protein polymorphisms of SHBG was not found to affect the levels of SHBG, total testosterone, and free testosterone. Protein polymorphism of SHBG was found to affect the insulin levels in the blood serum.

Key words: D327N mutation, insulin, protein polymorphism, sex hormone-binding globulin, testosterone


 
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How to Cite this Article
Pubmed Style

ML Edy Parwanto, Suweino Suweino, David Tjahjadi, Hardy Senjaya, Hosea Jaya Edy, Alfred Pakpahan. The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men. Int J Med Sci Public Health. 2016; 5(4): 799-806. doi:10.5455/ijmsph.2016.17122015293


Web Style

ML Edy Parwanto, Suweino Suweino, David Tjahjadi, Hardy Senjaya, Hosea Jaya Edy, Alfred Pakpahan. The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men. http://www.ijmsph.com/?mno=211136 [Access: August 24, 2019]. doi:10.5455/ijmsph.2016.17122015293


AMA (American Medical Association) Style

ML Edy Parwanto, Suweino Suweino, David Tjahjadi, Hardy Senjaya, Hosea Jaya Edy, Alfred Pakpahan. The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men. Int J Med Sci Public Health. 2016; 5(4): 799-806. doi:10.5455/ijmsph.2016.17122015293



Vancouver/ICMJE Style

ML Edy Parwanto, Suweino Suweino, David Tjahjadi, Hardy Senjaya, Hosea Jaya Edy, Alfred Pakpahan. The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men. Int J Med Sci Public Health. (2016), [cited August 24, 2019]; 5(4): 799-806. doi:10.5455/ijmsph.2016.17122015293



Harvard Style

ML Edy Parwanto, Suweino Suweino, David Tjahjadi, Hardy Senjaya, Hosea Jaya Edy, Alfred Pakpahan (2016) The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men. Int J Med Sci Public Health, 5 (4), 799-806. doi:10.5455/ijmsph.2016.17122015293



Turabian Style

ML Edy Parwanto, Suweino Suweino, David Tjahjadi, Hardy Senjaya, Hosea Jaya Edy, Alfred Pakpahan. 2016. The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men. International Journal of Medical Science and Public Health, 5 (4), 799-806. doi:10.5455/ijmsph.2016.17122015293



Chicago Style

ML Edy Parwanto, Suweino Suweino, David Tjahjadi, Hardy Senjaya, Hosea Jaya Edy, Alfred Pakpahan. "The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men." International Journal of Medical Science and Public Health 5 (2016), 799-806. doi:10.5455/ijmsph.2016.17122015293



MLA (The Modern Language Association) Style

ML Edy Parwanto, Suweino Suweino, David Tjahjadi, Hardy Senjaya, Hosea Jaya Edy, Alfred Pakpahan. "The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men." International Journal of Medical Science and Public Health 5.4 (2016), 799-806. Print. doi:10.5455/ijmsph.2016.17122015293



APA (American Psychological Association) Style

ML Edy Parwanto, Suweino Suweino, David Tjahjadi, Hardy Senjaya, Hosea Jaya Edy, Alfred Pakpahan (2016) The effect of sex hormone-binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men. International Journal of Medical Science and Public Health, 5 (4), 799-806. doi:10.5455/ijmsph.2016.17122015293





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