E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women

Alkhansa Osama Mohamed, Khalda Mirghani Hamza, Asaad Mohammed Ahmed Babker.

Cited by (1)

Abstract
Background: Pregnancy is a period of reproduction during which a woman carries one or more live offspring from implantation of a fertilized zygote in the uterus throughout gestation. There are several physiological changes that occur in pregnancy. Physiology of a normal pregnancy involves major changes in both the coagulation system and hematological parameters. These changes appear to be related to the development of the uteroplacental circulation and provide a protective mechanism during delivery.

Objective: To study the normal changes that occur to red blood cells (RBCs), white blood cells (WBCs), hemoglobin (Hb), platelets, and hemostatic profile (prothrombin time [PT] and partial thromboplastin time [PTT]) among pregnant Sudanese women and compare it within the three different trimesters.

Materials and Methods: A total of 50 apparently healthy pregnant women (gestational age 6–40 weeks) with age range between 20 and 40 years were recruited into the study. They were attending Khartoum teaching hospital, Khartoum, Sudan. There were no special preparation for subjects or questionnaires, and direct interviews were used to collect demographic and clinical data. After informed consent was obtained from the participants, 5 mL of venous blood was subsequently collected from an antecubital vein, with the subject comfortably seated, into ethylenediaminetetraacetic acid and citrate vacuum tubes. Hematological parameters including WBC, RBC, Hb, packed cell volume, and platelets were measured by Sysmex. The plasma clotting time, PT, and PTT were measured manually.

Results: The hematological parameters were represented as follows: mean value of WBCs was 7.580 cell/mm3, RBCs was 4.1 Χ l012/L, Hb was 11.79 g/dL, platelets was 256 Χ 109/L, PT mean value of the study group was 13.40 s, and PTT was 36.20 s.

Conclusion: There was no statistical significance in RBCs, Hb, platelets, PT, and PTT between pregnant women in the three different trimesters, whereas WBCs count showed significant differences among the three groups, the highest value was found in the second group followed by the third group and the lowest value found in the first group.

Key words: Sudanese pregnant women, hematological parameters, PT, PTT


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Alkhansa Osama Mohamed
Articles by Khalda Mirghani Hamza
Articles by Asaad Mohammed Ahmed Babker
on Google
on Google Scholar
Article Statistics
 Viewed: 3920
Downloaded: 513
Cited: 1


REFERENCES
1. US Department of Health and Human Services. Pregnancy: Condition Information. National Institutes of Health, 2013. Available at: http://www.nichd.nih.gov/ (last accessed on March 14, 2015).
2. Boundless. Introduction to pregnancy and human development. In: Boundless Anatomy and Physiology. Boston, MA: Boundless, 2015.
3. World Health Organization. International Statistical Classification of Diseases and Related Health Problems 10th revision. Geneva, Switzerland: WHO, 2006.
4. Costantine MM. Physiologic and pharmacokinetic changes in pregnancy. Front pharmacol 2014;5:65. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
5. Kraemer K, Zimmermann MB (Eds.). Nutritional Anemia. Basel, Switzerland: Sight and Life Press, 2007.
6. Paidas MJ, Hossain N, Shamsi TS, Rodger MA, Langhoff-Roos J, Lockwood CJ (Eds.). Hematologic changes in pregnancy. In: Hemostasis and Thrombosis in Obstetrics & Gynecology. Oxford, UK: Wiley-Blackwell, 2011. pp. 1–11.
7. Welt, Corrine K., et al. "Female Reproductive Physiology Background Reading".
8. Prisco D, Ciuti G, Falciani M. Hemostatic changes in normal pregnancy. Hematol Meet Rep 2009;1(10):1–5.
9. Ramsay M. Normal hematological changes during pregnancy and the puerperium. In: The Obstetric Hematology Manual, Pavord S, Hunt B (Eds.). Cambridge, UK: Cambridge University Press, 2010. pp. 1–11.
10. Haram K, Svendsen E, Abildgaard U. The HELLP syndrome: clinical issues and management. A review. BMC Pregnancy Childbirth 2009;9:8. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
11. Crocker IP, Baker PN, Fletcher J. Neutrophil function in pregnancy and rheumatoid arthritis. Ann Rheum Dis 2000;59(7):555–6. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
12. Chandra S, Tripathi AK, Mishra S, Amzarul M, Vaish AK. Physiological changes in hematological parameters during pregnancy. Indian J Hematol Blood Transfus 2012;28(3):144–6. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
13. Li H, Chen LF, Wang SY, Wang Y, Shi HM, Wang DQ. Correlation of hemogram changes during pregnancy of healthy women with postpartum blood transfusion. J experimental hematol 2012;20(5):1240–2.
14. Babiker HI, Awooda HA, Abdalla SE. Prothrombin time, activated partial thromboplastin time and platelets count in pregnant females and postpartum period with deep venous thrombosis. Int J Hematol Dis 2014;1(1):41–4.
15. Amah-Tariah FS, Ojeka SO, Dapper DV. Haematological values in pregnant women in Port Harcourt, Nigeria II: serum iron and transferrin, total and unsaturated iron binding capacity and some red cell and platelet indices. Niger J Physiol Sci 2011;26(2): 173–8.
16. Ichipi-Ifukor PC, Jacobs J, Ichipi-Ifukor RN, Ewrhe OL. Changes in haematological indices in normal pregnancy. Physiol J 2013; 2013(5):1–4. [DOI via Crossref]   
17. Boehlen F, Hohlfeld P, Extermann P, Perneger TV, de Moerloose P. Platelet count at term pregnancy: are reappraisal of the threshold. Obstet Gynecol 2000;95(1):29–33. [DOI via Crossref]   
18. Babker AMAAA, Gameel FEMH. Molecular characterization of Prothrombin G20210A gene mutations in pregnant Sudanese women with spontaneous recurrent abortions. RMJ 2015; 40(2):207–9.
19. Avwioro OG, Ezeobi JO, Oduola T, Fakunle OO. Prothrombin time and activated partial thromboplastin time in pregnant women in Southern Nigeria. J App Pharm Sci 2013;3(6):179–81.
20. Cerneca F, Ricci G, Simeone R, Malisano M, Alberico S, Guaschino S. Coagulation and fibrinolysis changes in normal pregnancy. Increased levels of procoagulants and reduced levels of inhibitors during pregnancy induce a hypercoagulable state, combined with a reactive fibrinolysis. Eur J Obstet Gynecol Reprod Biol 1997;73(1):31–6. [DOI via Crossref]   
21. Erhabor O, Isaac I, Muhammad A, Abdulrahaman Y, Ezimah A, Adias T. Some hemostatic parameters in women with obstetric hemorrhage in Sokoto, Nigeria. Int J Womens Health 2013; 5:285–91. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

This Article Cited By the following articles

Hematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M'diq-Fnideq provinces)
Pan Afr Med J 2018; 29(): .

1
 
How to Cite this Article
Pubmed Style

Alkhansa Osama Mohamed, Khalda Mirghani Hamza, Asaad Mohammed Ahmed Babker. Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women. Int J Med Sci Public Health. 2016; 5(3): 525-528. doi:10.5455/ijmsph.2016.30092015149


Web Style

Alkhansa Osama Mohamed, Khalda Mirghani Hamza, Asaad Mohammed Ahmed Babker. Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women. http://www.ijmsph.com/?mno=203390 [Access: August 24, 2019]. doi:10.5455/ijmsph.2016.30092015149


AMA (American Medical Association) Style

Alkhansa Osama Mohamed, Khalda Mirghani Hamza, Asaad Mohammed Ahmed Babker. Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women. Int J Med Sci Public Health. 2016; 5(3): 525-528. doi:10.5455/ijmsph.2016.30092015149



Vancouver/ICMJE Style

Alkhansa Osama Mohamed, Khalda Mirghani Hamza, Asaad Mohammed Ahmed Babker. Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women. Int J Med Sci Public Health. (2016), [cited August 24, 2019]; 5(3): 525-528. doi:10.5455/ijmsph.2016.30092015149



Harvard Style

Alkhansa Osama Mohamed, Khalda Mirghani Hamza, Asaad Mohammed Ahmed Babker (2016) Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women. Int J Med Sci Public Health, 5 (3), 525-528. doi:10.5455/ijmsph.2016.30092015149



Turabian Style

Alkhansa Osama Mohamed, Khalda Mirghani Hamza, Asaad Mohammed Ahmed Babker. 2016. Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women. International Journal of Medical Science and Public Health, 5 (3), 525-528. doi:10.5455/ijmsph.2016.30092015149



Chicago Style

Alkhansa Osama Mohamed, Khalda Mirghani Hamza, Asaad Mohammed Ahmed Babker. "Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women." International Journal of Medical Science and Public Health 5 (2016), 525-528. doi:10.5455/ijmsph.2016.30092015149



MLA (The Modern Language Association) Style

Alkhansa Osama Mohamed, Khalda Mirghani Hamza, Asaad Mohammed Ahmed Babker. "Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women." International Journal of Medical Science and Public Health 5.3 (2016), 525-528. Print. doi:10.5455/ijmsph.2016.30092015149



APA (American Psychological Association) Style

Alkhansa Osama Mohamed, Khalda Mirghani Hamza, Asaad Mohammed Ahmed Babker (2016) Physiological changes in some hematological and coagulation profile among Sudanese healthy pregnant women. International Journal of Medical Science and Public Health, 5 (3), 525-528. doi:10.5455/ijmsph.2016.30092015149





Most Viewed Articles
  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Elevated levels of serum uric acid, creatinine or urea in preeclamptic women
    Magna Manjareeka, Sitikantha Nanda
    Int J Med Sci Public Health. 2013; 2(1): 43-47
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.43-47

  • Maternal and fetal outcome in oligohydramnios- Study of 100 cases
    Krishna Jagatia, Nisha Singh, Sachin Patel
    Int J Med Sci Public Health. 2013; 2(3): 724-727
    » Abstract & References » doi: 10.5455/ijmsph.2013.070520132

  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Prevalence and pattern of substance abuse among school childern in nothern India: A rapid assesment study
    Syed Shuja Qadri, RKD Goel, Jagjeet Singh, Surendra Kumar Ahluwalia, Rambha Pathak, Humaira Bashir
    Int J Med Sci Public Health. 2013; 2(2): 273-282
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.271-280

  • Most Downloaded
  • Minor disorder of pregnancy and its home management
    Lata Gururani, Atul Kumar, Gomathi Mahalingam
    Int J Med Sci Public Health. 2016; 5(4): 684-687
    » Abstract & References » doi: 10.5455/ijmsph.2016.03082015111

  • Association between serum ferritin and thyroid hormone profile in hypothyroidism
    Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair
    Int J Med Sci Public Health. 2015; 4(6): 863-865
    » Abstract & References » doi: 10.5455/ijmsph.2015.24012015174

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Effect of sleep deprivation on the attitude and performance of medical students, Riyadh, Saudi Arabia
    Hussein Saad Amin, Ibrahim Salamah Almazroua, Abdullah Sulaiman Alsahlan, Mohammed Abdullah Alrishan, Houssam Mourad Elmourad, Mohammed Mansour Alotaibi, Abdulaziz Ibrahim Almohaisin
    Int J Med Sci Public Health. 2016; 5(3): 575-580
    » Abstract & References » doi: 10.5455/ijmsph.2016.17112015207

  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Epidemiology and prevalence of dermatological diseases among schoolchildren of Medak district, Telangana—a clinical survey
    Lakshmi Kumari Villa, Gopi Krishna
    Int J Med Sci Public Health. 2016; 5(7): 1475-1478
    » Abstract & References » doi: 10.5455/ijmsph.2016.28102015238

  • Gunthers with haemolytic anaemia extremly rare: A case report
    Nilesh Kumar, Ankur Varshney, Arvind Anand, Dibyaranjan Behera, Ravi Anand, Ashutosh Tiwari
    Int J Med Sci Public Health. 2013; 2(2): 472-474
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.313-315

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Most Cited Articles
  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6
    Cited : 25 times [Click to see citing articles]

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11
    Cited : 13 times [Click to see citing articles]

  • Design of fuzzy expert system for diagnosis of cardiac diseases
    Smita Sushil Sikchi , Sushil Sikchi , M S ALI
    Int J Med Sci Public Health. 2013; 2(1): 56-61
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.56-61
    Cited : 9 times [Click to see citing articles]

  • Sugammadex associate persistant bradycardia
    Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu
    Int J Med Sci Public Health. 2014; 3(3): 372-374
    » Abstract & References » doi: 10.5455/ijmsph.2013.251220131
    Cited : 8 times [Click to see citing articles]

  • Migration and health-care access: Barriers to access government health services by migrant tribal community living in an eastern Indian city
    Suchismita Mishra, Yadlapalli S Kusuma, Bontha V Babu
    Int J Med Sci Public Health. 2015; 4(1): 101-108
    » Abstract & References » doi: 10.5455/ijmsph.2015.0110201424
    Cited : 7 times [Click to see citing articles]

  • Clinico-microbiological profile of women with vaginal discharge in a tertiary care hospital of northern India
    Varsha Chaudhary, Ved Prakesh, Kian Agarwal, Vijender Kumar Agrawal, Arun Singh, Sachin Pandey
    Int J Med Sci Public Health. 2012; 1(2): 75-80
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.75-80
    Cited : 6 times [Click to see citing articles]

  • Correlation between obesity and cardio respiratory fitness
    Prabha Setty, BV Padmanabha, BR Doddamani
    Int J Med Sci Public Health. 2013; 2(2): 300-304
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.298-302
    Cited : 6 times [Click to see citing articles]

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42
    Cited : 6 times [Click to see citing articles]

  • Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile
    Sachin Chandrakant Deorukhkar, Santosh Saini
    Int J Med Sci Public Health. 2013; 2(3): 533-538
    » Abstract & References » doi: 10.5455/ijmsph.2013.080320131
    Cited : 6 times [Click to see citing articles]

  • Initial default among tuberculosis patients diagnosed in selected medical colleges of Puducherry: issues and possible interventions
    Divija Pillai, Anil J Purty, Stalin Prabakaran, Zile Singh, Govindarajan Soundappan, Velavan Anandan
    Int J Med Sci Public Health. 2015; 4(7): 957-960
    » Abstract & References » doi: 10.5455/ijmsph.2015.30012015196
    Cited : 6 times [Click to see citing articles]