E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Comparative evaluation of amisulpride and escitalopram on Hamilton Depression Rating Scale among depression patients in a tertiary care teaching hospital in Nepal

Vijay Kaul, Shaktibala Dutta, Mirza Atif Beg, Nand Kishore Singh, Shalu Bawa, Mohammad Anjoom, Srihari Dutta.

Abstract
Background: Depression is a considerable global public health problem and is a major cause of disability and premature death. It results in poor quality of life in patients and caregivers.

Objective: The present study was conducted to compare efficacy and safety of amisulpride and escitalopram, using Hamilton Depression Rating Scale (HAM-D) among depression patients in a tertiary care teaching hospital in Nepal.

Material and Methods: This study was conducted in the Department of Neuropsychiatry, Nepalgunj Medical College and a tertiary care teaching hospital in Nepal for a period of 1 year.<AQ: Please check the edit made to this sentence.> A total of 117 depression patients were randomly selected and divided into two groups. Group I (58 patients) received amisulpride 50 mg/day orally and Group II (59 patients) were given escitalopram 10 mg/day orally. The patients were followed up at 4, 8, and 15 weeks. The efficacy of the drugs was calculated by HAM-D. Adverse drug reactions were monitored at every follow-up. GraphPad Instat, version 3.0, tool was used for statistical analysis and p-value <0.05 was considered significant.

Results: HAM-D score in the group receiving amisulpride at 0 and 15 weeks was 16.92 ± 0.35 and 7.87 ± 0.29 (p < 0.0001). HAM-D score in group receiving escitalopram at 0 and 15 weeks was 17.09 ± 0.39 and 6.63 ± 0.39 (p < 0.0001). Intergroup comparison at 15 weeks was more significant for escitalopram (p < 0.05). Gastrointestinal disturbances, sexual disturbances, amenorrhoea lactation, agitation and insomnia were the commonly encountered adverse drug reactions.

Conclusion: The present study showed both amisulpride and escitalopram were highly effective in improving the HAM-D score and in the treatment of depression. But intergroup comparison showed greater reduction in HAM-D score in patients receiving escitalopram.

Key words: Depression, amisulpride, escitalopram, Hamilton Depression Rating Scale (HAM-D)


 
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How to Cite this Article
Pubmed Style

Vijay Kaul, Shaktibala Dutta, Mirza Atif Beg, Nand Kishore Singh, Shalu Bawa, Mohammad Anjoom, Srihari Dutta. Comparative evaluation of amisulpride and escitalopram on Hamilton Depression Rating Scale among depression patients in a tertiary care teaching hospital in Nepal. Int J Med Sci Public Health. 2015; 4(5): 642-646. doi:10.5455/ijmsph.2015.23012015132


Web Style

Vijay Kaul, Shaktibala Dutta, Mirza Atif Beg, Nand Kishore Singh, Shalu Bawa, Mohammad Anjoom, Srihari Dutta. Comparative evaluation of amisulpride and escitalopram on Hamilton Depression Rating Scale among depression patients in a tertiary care teaching hospital in Nepal. http://www.ijmsph.com/?mno=178290 [Access: July 18, 2019]. doi:10.5455/ijmsph.2015.23012015132


AMA (American Medical Association) Style

Vijay Kaul, Shaktibala Dutta, Mirza Atif Beg, Nand Kishore Singh, Shalu Bawa, Mohammad Anjoom, Srihari Dutta. Comparative evaluation of amisulpride and escitalopram on Hamilton Depression Rating Scale among depression patients in a tertiary care teaching hospital in Nepal. Int J Med Sci Public Health. 2015; 4(5): 642-646. doi:10.5455/ijmsph.2015.23012015132



Vancouver/ICMJE Style

Vijay Kaul, Shaktibala Dutta, Mirza Atif Beg, Nand Kishore Singh, Shalu Bawa, Mohammad Anjoom, Srihari Dutta. Comparative evaluation of amisulpride and escitalopram on Hamilton Depression Rating Scale among depression patients in a tertiary care teaching hospital in Nepal. Int J Med Sci Public Health. (2015), [cited July 18, 2019]; 4(5): 642-646. doi:10.5455/ijmsph.2015.23012015132



Harvard Style

Vijay Kaul, Shaktibala Dutta, Mirza Atif Beg, Nand Kishore Singh, Shalu Bawa, Mohammad Anjoom, Srihari Dutta (2015) Comparative evaluation of amisulpride and escitalopram on Hamilton Depression Rating Scale among depression patients in a tertiary care teaching hospital in Nepal. Int J Med Sci Public Health, 4 (5), 642-646. doi:10.5455/ijmsph.2015.23012015132



Turabian Style

Vijay Kaul, Shaktibala Dutta, Mirza Atif Beg, Nand Kishore Singh, Shalu Bawa, Mohammad Anjoom, Srihari Dutta. 2015. Comparative evaluation of amisulpride and escitalopram on Hamilton Depression Rating Scale among depression patients in a tertiary care teaching hospital in Nepal. International Journal of Medical Science and Public Health, 4 (5), 642-646. doi:10.5455/ijmsph.2015.23012015132



Chicago Style

Vijay Kaul, Shaktibala Dutta, Mirza Atif Beg, Nand Kishore Singh, Shalu Bawa, Mohammad Anjoom, Srihari Dutta. "Comparative evaluation of amisulpride and escitalopram on Hamilton Depression Rating Scale among depression patients in a tertiary care teaching hospital in Nepal." International Journal of Medical Science and Public Health 4 (2015), 642-646. doi:10.5455/ijmsph.2015.23012015132



MLA (The Modern Language Association) Style

Vijay Kaul, Shaktibala Dutta, Mirza Atif Beg, Nand Kishore Singh, Shalu Bawa, Mohammad Anjoom, Srihari Dutta. "Comparative evaluation of amisulpride and escitalopram on Hamilton Depression Rating Scale among depression patients in a tertiary care teaching hospital in Nepal." International Journal of Medical Science and Public Health 4.5 (2015), 642-646. Print. doi:10.5455/ijmsph.2015.23012015132



APA (American Psychological Association) Style

Vijay Kaul, Shaktibala Dutta, Mirza Atif Beg, Nand Kishore Singh, Shalu Bawa, Mohammad Anjoom, Srihari Dutta (2015) Comparative evaluation of amisulpride and escitalopram on Hamilton Depression Rating Scale among depression patients in a tertiary care teaching hospital in Nepal. International Journal of Medical Science and Public Health, 4 (5), 642-646. doi:10.5455/ijmsph.2015.23012015132





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