E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Second-line drug resistance patterns among patients with multidrug-resistant tuberculosis of Gujarat, western India

Sachin M Patel, Mitesh H Patel, Sumeeta T Soni, Mahendra M Vegad.

Cited by (1)

Abstract
Background: Lack of laboratory diagnostic capacity is a crucial barrier preventing an effective response to early and appropriate case detection and treatment of multidrug-resistant tuberculosis (MDR-TB). To date, limited representative drug resistance data are available from India on second-line drug (SLD) resistance.

Objectives: To study SLD resistance patterns in MDR-TB patients of Gujarat, western India.
Materials and Methods: Antituberculosis drug susceptibility testing of 50 MDR-TB isolates particularly for SLDs, namely p-aminosalicylic acid, ciprofloxacin, amikacin, D-cycloserine, kanamycin, and ethionamide, was conducted on solid Lowenstein–Jensen medium using the 1% proportion sensitivity method.

Results: Of 50 MDR-TB isolates tested, 24 (24/50, 48%) were found to be resistant to one or more SLDs. Of 50 MDR-TB isolates, 18 (18/50, 36%) showed resistance to ethionamide, 13 (13/50, 26%) to D-cycloserine, 11 (11/50, 22%) to ciprofloxacin, 7 (7/50, 14%) to kanamycin, 6 (6/50, 12%) to p-aminosalicylic acid, and 5 (5/50, 10%) to Amikacin.

Conclusion: High levels of SLD resistance were found to be present in this study. There is an urgent need for more control and rational use of the widely available fluoroquinolones and other SLDs outside of the Revised National Tuberculosis Control Programme, by both the public and the private health sectors in India.

Key words: Drug resistance, MDR-TB, second-line drugs


 
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This Article Cited By the following articles

A study on pattern of resistance to second line anti tubercular drugs among multi drug resistant tuberculosis patients
Indian Journal of Tuberculosis 2018; (): .

1
 
How to Cite this Article
Pubmed Style

Sachin M Patel, Mitesh H Patel, Sumeeta T Soni, Mahendra M Vegad. Second-line drug resistance patterns among patients with multidrug-resistant tuberculosis of Gujarat, western India. Int J Med Sci Public Health. 2015; 4(5): 639-641. doi:10.5455/ijmsph.2015.19012015130


Web Style

Sachin M Patel, Mitesh H Patel, Sumeeta T Soni, Mahendra M Vegad. Second-line drug resistance patterns among patients with multidrug-resistant tuberculosis of Gujarat, western India. http://www.ijmsph.com/?mno=177915 [Access: April 23, 2019]. doi:10.5455/ijmsph.2015.19012015130


AMA (American Medical Association) Style

Sachin M Patel, Mitesh H Patel, Sumeeta T Soni, Mahendra M Vegad. Second-line drug resistance patterns among patients with multidrug-resistant tuberculosis of Gujarat, western India. Int J Med Sci Public Health. 2015; 4(5): 639-641. doi:10.5455/ijmsph.2015.19012015130



Vancouver/ICMJE Style

Sachin M Patel, Mitesh H Patel, Sumeeta T Soni, Mahendra M Vegad. Second-line drug resistance patterns among patients with multidrug-resistant tuberculosis of Gujarat, western India. Int J Med Sci Public Health. (2015), [cited April 23, 2019]; 4(5): 639-641. doi:10.5455/ijmsph.2015.19012015130



Harvard Style

Sachin M Patel, Mitesh H Patel, Sumeeta T Soni, Mahendra M Vegad (2015) Second-line drug resistance patterns among patients with multidrug-resistant tuberculosis of Gujarat, western India. Int J Med Sci Public Health, 4 (5), 639-641. doi:10.5455/ijmsph.2015.19012015130



Turabian Style

Sachin M Patel, Mitesh H Patel, Sumeeta T Soni, Mahendra M Vegad. 2015. Second-line drug resistance patterns among patients with multidrug-resistant tuberculosis of Gujarat, western India. International Journal of Medical Science and Public Health, 4 (5), 639-641. doi:10.5455/ijmsph.2015.19012015130



Chicago Style

Sachin M Patel, Mitesh H Patel, Sumeeta T Soni, Mahendra M Vegad. "Second-line drug resistance patterns among patients with multidrug-resistant tuberculosis of Gujarat, western India." International Journal of Medical Science and Public Health 4 (2015), 639-641. doi:10.5455/ijmsph.2015.19012015130



MLA (The Modern Language Association) Style

Sachin M Patel, Mitesh H Patel, Sumeeta T Soni, Mahendra M Vegad. "Second-line drug resistance patterns among patients with multidrug-resistant tuberculosis of Gujarat, western India." International Journal of Medical Science and Public Health 4.5 (2015), 639-641. Print. doi:10.5455/ijmsph.2015.19012015130



APA (American Psychological Association) Style

Sachin M Patel, Mitesh H Patel, Sumeeta T Soni, Mahendra M Vegad (2015) Second-line drug resistance patterns among patients with multidrug-resistant tuberculosis of Gujarat, western India. International Journal of Medical Science and Public Health, 4 (5), 639-641. doi:10.5455/ijmsph.2015.19012015130





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