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Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study

Nilesh Thakor, Samir Bhagora, Unnati Asari, Ashish Kharadi, Jyotsna Pandor, Dipak Prajapati.

Cited by (2)

Abstract
Background: Anemia is one of the major public health problems in the developing countries. More than 70% of pregnant women in Southeast Asian region have nutritional anemia, which affects both the mother and the newborn and subsequent child and later adult.

Objective: To evaluate the response and effect of parenteral iron sucrose complex therapy in iron-deficiency anemia in pregnancy.

Material and Methods: A prospective observational study was conducted at VS General Hospital, Ahmedabad, Gujarat, India, from September 2009 to November 2011. A total of 75 Antenatal women, between 26 and 32 weeks of pregnancy with hemoglobin level between 5–9 g%, were selected for study by purposive sampling. They were given intravenous iron sucrose complex in a dose of 200 mg (2 ampoules of 5 ml each) in 100 mL normal saline for 15–20 minutes, on alternate day. Repeat complete blood count was done after 6 weeks.

Results: Of 75 women, 36 (48%) were in age group of 20–24 years and 49 (65.2%) were 27–29 weeks pregnant. The mean hemoglobin level increased from 7.8 ± 0.61 to 10.1 ± 0.73 g% (p<0.001) after 6 weeks of therapy. There was significant rise in mean corpuscular volume levels (from 67.8 ± 5.0 to 79.2 ± 2.3 fL; p<0.001). 91% of patients treated for anemia delivered at full term, either vaginally (65.33%) or by lower segment cesarean section (25.3%). Most of the delivered babies (80%) had birth weight of more than 2.5 kg. No major side effects or anaphylactic reactions were observed in the women during the study period.

Conclusion: Parenteral iron therapy was effective in increasing hemoglobin levels and other hematological parameters in pregnant women with moderate-to-severe anemia. If used in time, this treatment will certainly help to reduce the risk of maternal and fetal complications as well as to reduce the risk of blood transfusion during peripartum period.

Key words: Anemia, iron deficiency, iron sucrose complex, parenteral iron therapy, MCV


 
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This Article Cited By the following articles

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Aust N Z J Obstet Gynaecol 2018; 58(1): 22.

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Safety and efficacy of intravenous iron polymaltose, iron sucrose and ferric carboxymaltose in pregnancy: A systematic review
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How to Cite this Article
Pubmed Style

Nilesh Thakor, Samir Bhagora, Unnati Asari, Ashish Kharadi, Jyotsna Pandor, Dipak Prajapati. Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study. Int J Med Sci Public Health. 2015; 4(1): 11-14. doi:10.5455/ijmsph.2015.100920145


Web Style

Nilesh Thakor, Samir Bhagora, Unnati Asari, Ashish Kharadi, Jyotsna Pandor, Dipak Prajapati. Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study. http://www.ijmsph.com/?mno=168982 [Access: August 24, 2019]. doi:10.5455/ijmsph.2015.100920145


AMA (American Medical Association) Style

Nilesh Thakor, Samir Bhagora, Unnati Asari, Ashish Kharadi, Jyotsna Pandor, Dipak Prajapati. Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study. Int J Med Sci Public Health. 2015; 4(1): 11-14. doi:10.5455/ijmsph.2015.100920145



Vancouver/ICMJE Style

Nilesh Thakor, Samir Bhagora, Unnati Asari, Ashish Kharadi, Jyotsna Pandor, Dipak Prajapati. Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study. Int J Med Sci Public Health. (2015), [cited August 24, 2019]; 4(1): 11-14. doi:10.5455/ijmsph.2015.100920145



Harvard Style

Nilesh Thakor, Samir Bhagora, Unnati Asari, Ashish Kharadi, Jyotsna Pandor, Dipak Prajapati (2015) Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study. Int J Med Sci Public Health, 4 (1), 11-14. doi:10.5455/ijmsph.2015.100920145



Turabian Style

Nilesh Thakor, Samir Bhagora, Unnati Asari, Ashish Kharadi, Jyotsna Pandor, Dipak Prajapati. 2015. Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study. International Journal of Medical Science and Public Health, 4 (1), 11-14. doi:10.5455/ijmsph.2015.100920145



Chicago Style

Nilesh Thakor, Samir Bhagora, Unnati Asari, Ashish Kharadi, Jyotsna Pandor, Dipak Prajapati. "Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study." International Journal of Medical Science and Public Health 4 (2015), 11-14. doi:10.5455/ijmsph.2015.100920145



MLA (The Modern Language Association) Style

Nilesh Thakor, Samir Bhagora, Unnati Asari, Ashish Kharadi, Jyotsna Pandor, Dipak Prajapati. "Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study." International Journal of Medical Science and Public Health 4.1 (2015), 11-14. Print. doi:10.5455/ijmsph.2015.100920145



APA (American Psychological Association) Style

Nilesh Thakor, Samir Bhagora, Unnati Asari, Ashish Kharadi, Jyotsna Pandor, Dipak Prajapati (2015) Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: A longitudinal study. International Journal of Medical Science and Public Health, 4 (1), 11-14. doi:10.5455/ijmsph.2015.100920145





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