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Metaplastic breast cancer : Pathological subtypes, clinical presentation, imaging characteristics, Immunohistochemistry, treatment and prognosis

Farooq Ahmed Wani.

Cited by (1)

Abstract
Metaplastic breast cancer is a rare subtype of breast cancer that is histologically heterogeneous, being composed of both sarcomatous and epithelial components. It presents as rapidly growing palpable masses. Incidence of nodal metastasis is low, as compared to intraductal carcinoma, but it has a high metastatic potential and more chances of local recurrence. Many different pathological classifications are available, the most popular being "Wargotz and Norris classification". Imaging features mimic those of intraductal carcinoma. Immunohistochemically, these tumors show a basal/myoepithelial phenotype with positivity for cytokeratins, AE1/AE3, smooth muscle actin, p63, alpha B-crystallin, etc. These tumors show no or very low positivity for hormone receptors or HER-2 over expression. Therefore, they are often called triple negative carcinomas. They are aggressive tumors with suboptimal response to standard chemotherapy regimens. Overall prognosis of the patients with metaplastic breast cancer is worse than the patients with intraductal breast carcinoma. Further research is needed for formulating targeted therapies for this aggressive tumor.

Key words: Metaplastic Breast Cancer; Intraductal Cancer; Tumor Size


 
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This Article Cited By the following articles

Multimodality Imaging Findings of Metaplastic Breast Carcinomas
Ultrasound Quarterly 2018; 34(2): 88.

1
 
How to Cite this Article
Pubmed Style

Farooq Ahmed Wani. Metaplastic breast cancer : Pathological subtypes, clinical presentation, imaging characteristics, Immunohistochemistry, treatment and prognosis. Int J Med Sci Public Health. 2014; 3(9): 1029-1033. doi:10.5455/ijmsph.2014.090720141


Web Style

Farooq Ahmed Wani. Metaplastic breast cancer : Pathological subtypes, clinical presentation, imaging characteristics, Immunohistochemistry, treatment and prognosis. http://www.ijmsph.com/?mno=162176 [Access: August 24, 2019]. doi:10.5455/ijmsph.2014.090720141


AMA (American Medical Association) Style

Farooq Ahmed Wani. Metaplastic breast cancer : Pathological subtypes, clinical presentation, imaging characteristics, Immunohistochemistry, treatment and prognosis. Int J Med Sci Public Health. 2014; 3(9): 1029-1033. doi:10.5455/ijmsph.2014.090720141



Vancouver/ICMJE Style

Farooq Ahmed Wani. Metaplastic breast cancer : Pathological subtypes, clinical presentation, imaging characteristics, Immunohistochemistry, treatment and prognosis. Int J Med Sci Public Health. (2014), [cited August 24, 2019]; 3(9): 1029-1033. doi:10.5455/ijmsph.2014.090720141



Harvard Style

Farooq Ahmed Wani (2014) Metaplastic breast cancer : Pathological subtypes, clinical presentation, imaging characteristics, Immunohistochemistry, treatment and prognosis. Int J Med Sci Public Health, 3 (9), 1029-1033. doi:10.5455/ijmsph.2014.090720141



Turabian Style

Farooq Ahmed Wani. 2014. Metaplastic breast cancer : Pathological subtypes, clinical presentation, imaging characteristics, Immunohistochemistry, treatment and prognosis. International Journal of Medical Science and Public Health, 3 (9), 1029-1033. doi:10.5455/ijmsph.2014.090720141



Chicago Style

Farooq Ahmed Wani. "Metaplastic breast cancer : Pathological subtypes, clinical presentation, imaging characteristics, Immunohistochemistry, treatment and prognosis." International Journal of Medical Science and Public Health 3 (2014), 1029-1033. doi:10.5455/ijmsph.2014.090720141



MLA (The Modern Language Association) Style

Farooq Ahmed Wani. "Metaplastic breast cancer : Pathological subtypes, clinical presentation, imaging characteristics, Immunohistochemistry, treatment and prognosis." International Journal of Medical Science and Public Health 3.9 (2014), 1029-1033. Print. doi:10.5455/ijmsph.2014.090720141



APA (American Psychological Association) Style

Farooq Ahmed Wani (2014) Metaplastic breast cancer : Pathological subtypes, clinical presentation, imaging characteristics, Immunohistochemistry, treatment and prognosis. International Journal of Medical Science and Public Health, 3 (9), 1029-1033. doi:10.5455/ijmsph.2014.090720141





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